EpiSante Biomedical | Establishment and Consulting of LDTs Lab | DNA methylation analysis | cancer management

DNA methylation maintains many important physiological functions, such as embryonic development, immune response, gene imprinting, female X chromosome inactivation, and maintaining genomic stability. If DNA methylation is imbalanced, it can lead to various health problems and diseases. For example, symptoms like headaches, insomnia, and anxiety. It can even lead to mental/neuro disorders, cardiovascular diseases, diabetes, obesity, autoimmune diseases, aging, and cancer.

DNA methylation can be influenced by daily diet, lifestyle, stress, medication, exercise, and environmental factors. For example, exposure to pollutants, heavy metals, environmental toxins, or endocrine disruptors can interfere with normal methylation functions. Conversely, good dietary habits and lifestyle, as well as regular and appropriate exercise, can maintain normal methylation status in the body, contributing to anti-inflammatory, antioxidant, and anti-aging effects.

Abnormal global DNA methylation levels have been linked to various diseases. Hypomethylation is associated with certain cancers, neurological disorders, and cardiovascular diseases, while hypermethylation is linked to other types of cancer, autoimmune diseases, and aging. Since DNA methylation is a reversible process, it can be modulated through dietary and lifestyle changes to improve health outcomes. Understanding the relationship between global DNA methylation and disease can aid in disease prevention.