EpiSante Biomedical | MethClock-Biological Age Anti-aging Test | DNA methylation analysis | cancer management

DNA methylation patterns change during the aging process and disease development. These changes can be used to assess and evaluate the aging and disease status of human organs and systems. Currently, DNA methylation patterns are widely used as a measure of biological age, termed the "methylation clock." Unlike chronological age, which is calculated from birth, biological age provides a better measure of an individual's bodily functions and aging rate. Due to factors such as lifestyle and genetics, biological age may differ from chronological age. A 50-year-old with healthy habits may have a younger biological age than a 40-year-old who smokes and drinks daily.

A randomized controlled trial demonstrated that an 8-week dietary and lifestyle intervention (including a healthy diet, sleep, exercise, relaxation techniques, and supplementation with probiotics and plant-based nutrients) resulted in a 3.23-year reduction in biological age as assessed by the methylation clock compared to a control group without intervention (p = 0.018). (Aging 2021;13:9419–9432)

Leukemia patients have a higher physiological age compared to the general population, while individuals who have received NK cell infusion have a lower physiological age.

AML: Acute myeloid leukemia
H and LX: Healthy people
T:people with NK cell infusion